Prescriptions to support longevity

Longevity medicine is a proactive approach to health that uses data, biomarker testing, and evidence-based protocols and interventions to support healthy aging. Immortals Medicine is a telehealth platform designed by longevity experts that connects you with licensed physicians who can prescribe medication protocols to support longevity, if appropriate.

Prescriptions are subject to assessment by a provider and are not guaranteed. This content is for informational purposes only and does not constitute medical advice, treatment or a diagnosis.

Bryan Johnson takes a range of prescription medications to support longevity, including Acarbose, Daily Tadalafil (Generic for Cialis®), Minoxidil (both oral and topical), Metformin (cycling), Tretinoin, Jardiance®, Candesartan and Repatha®. These are all FDA-approved medications, often prescribed off-label for longevity support.

Bryan’s prescription stack is calibrated to his unique biomarkers, health history, and specific goals. What works for him may not be what's right for your biology. 

This is why a licensed physician reviews your specific biology to understand your needs. Your assigned doctor reviews your medical history and health goals, then recommends prescription treatment — often off-label — personalized to your data. The medications available through Immortals cover a broad range of longevity goals, curated by clinicians who specialize in this field.

Every prescription is subject to an individual medical consultation and the professional judgment of the treating physician.

Tadalafil (Generic for Cialis®) is often prescribed as an FDA-approved medication to treat specific conditions, including erectile dysfunction, but it’s an emerging treatment prescribed off-label by some providers within a longevity medicine framework.

The same mechanism that causes ED (blood vessels losing their ability to relax and open) is often an early stage of cardiovascular disease. 

Because Tadalafil works by improving how blood vessels function throughout the entire body — not just in the penis — researchers started looking at whether it might also protect the heart and brain. The data so far is striking: large observational studies show men who take PDE5 inhibitors like Tadalafil have significantly lower rates of heart attacks, heart failure, stroke, and even Alzheimer's disease. While the research in females is less abundant, the mechanism of action should, theoretically have the same effect on female cardiovascular health.

Through Immortals Medicine, a licensed physician reviews your medical history and health goals to determine whether tadalafil is appropriate for your biology. 

The vascular mechanism that makes tadalafil relevant for longevity applies to women too.

Nitric oxide signaling and PDE5 activity govern blood vessel function in everyone — not exclusively in men. Tadalafil is already FDA-approved for pulmonary arterial hypertension, a condition that affects women at higher rates than men. That approval is based on demonstrated vascular benefit in female patients.

The cardiovascular longevity data (heart failure, stroke, and Alzheimer's associations) comes primarily from observational cohorts of men with ED, the population where PDE5 inhibitors have been used at scale. The endothelial mechanism doesn't change by sex. Research into tadalafil and female cardiovascular outcomes is ongoing.

Through Immortals Medicine, a licensed physician reviews female patients' medical history, cardiovascular risk profile, and health goals to determine whether tadalafil is appropriate. 

Metformin is an FDA-approved medication for type 2 diabetes that has been extensively researched for its role in healthy aging. It is commonly used off-label within longevity protocols to support metabolic health. Through Immortals Medicine, a licensed healthcare provider reviews your biomarkers and health history to determine if metformin is appropriate for your individual needs.

Compounded medications are customized prescriptions prepared by licensed compounding pharmacies. These are tailored to a patient’s specific clinical needs, such as personalizing a dose based on health goals for which commercially available doses may not be appropriate. A compounded medication may also combine multiple active ingredients to suit a patient's unique needs. While these medications use doctor-trusted ingredients from licensed pharmacies, the compounded formularies are not FDA-approved.

Immortals Medicine is available to adults 18+ in eligible U.S. states only. Certain medications are not available in certain states.

Eligibility for any medication is determined solely by a licensed healthcare provider based on your medical history, biomarkers, and an individual clinical evaluation. The 5-10 minute intake form is the first step to determine which treatments you may be eligible for. A physician reviews every case before any prescription is issued.

Pricing varies by medication and dose. Immortals Medicine has no membership fees or insurance requirements. You are only charged after a physician approves your treatment. 

The intake takes about 10 minutes, with doctor review typically completed within 24 hours. Once reviewed and if prescribed, most medications ship in 2–5 business days. The cost of your subscription includes ongoing, unlimited messaging support with your healthcare provider regarding your protocol for 12 months. 

Yes. Immortals Medicine offers female-specific longevity medications including estradiol and tadalafil for longevity, prescribed by licensed physicians.

Most longevity medicine wasn't built for women. The large outcome trials, the protocol defaults, and the dosing assumptions were developed in male cohorts, applied to women as an afterthought. The underrepresentation of women in longevity research is a major gap. It's why most longevity platforms default to a women's version of a male protocol.

Immortals Medicine approaches female longevity differently.

A licensed physician reviews your medical history, biomarkers, and health goals. Perimenopause, menopause, and cycle phase are factored into what's recommended and how it's dosed. BryanAI's protocols are adjusted for female biology at every life stage. Immortals is a longevity medicine platform built to serve female biology on its own terms.

While many platforms focus on single categories like hair or weight loss, Bryan Johnson’s clinical team built Immortals Medicine on the comprehensive principles of longevity medicine. 

The medications available through Immortals Medicine are inspired by Bryan Johnson's Protocol. The prescribing physicians prioritize proactive health management. In the Immortals app, your prescriptions can be viewed alongside your biomarkers and wearable data, creating a centralized hub for your longevity strategy.