Immortals Medicine amber prescription bottle labeled Jardiance on a blue background, FDA-approved empagliflozin type 2 diabetes medication for glucose control in the Bryan Johnson Blueprint longevity protocol

“I take Jardiance®, an SGLT-2 inhibitor, daily. There is good preclinical evidence supporting SGLT-2 inhibitors as longevity interventions and calorie restriction mimetics, complemented by robust human trial data showing heart and kidney protection.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
  • What Bryan takes
  • Support longevity
  • Support weight loss

Jardiance®

(empagliflozin)

From $1,200/mo*

$1,500/mo

Blocks the kidney protein that pulls glucose back into your blood, helping excrete sugar.
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Not sure? Take the quiz

*Billed quarterly with a three-month commitment paid up front.
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HSA/FSA
reimbursable

Founded by Bryan
Johnson
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No insurance
required

Fast, discreet
shipping
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Licensed US
pharmacies

Unlimited follow-up with licensed physicians
Shield with medical cross icon representing HSA and FSA eligibility at Blueprint Immortals

HSA/FSA
reimbursable
Dollar sign icon representing transparent pricing at Blueprint Immortals

No insurance
required
Laboratory flask with checkmark icon representing tested formulas at Blueprint Immortals

Licensed US
pharmacies

Founded by Bryan Johnson

Fast, discreet shipping

Unlimited follow-up with licensed physicians

$0

Membership fees

“I take Jardiance®, an SGLT-2 inhibitor, daily. There is good preclinical evidence supporting SGLT-2 inhibitors as longevity interventions and calorie restriction mimetics, complemented by robust human trial data showing heart and kidney protection.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
WHY JARDIANCE®

Your kidneys reabsorb glucose. Jardiance® reduces that reabsorption.

With Jardiance® Without Jardiance®
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

HOW JARDIANCE® WORKS

Lowers glucose.

Supports metabolic health.

Jardiance® inhibits SGLT2 in the kidneys, the transporter that pulls glucose and sodium back into your blood. This helps support cardiovascular health, kidney function, and metabolic health.
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Inhibits SGLT2

Jardiance® binds to and inhibits SGLT2, the primary transporter in the kidneys responsible for reabsorbing filtered glucose back into the bloodstream.
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Reduces cardiometabolic load

In clinical trials, daily dosing produced reductions in cardiovascular death, heart failure hospitalization, and progression of chronic kidney disease.
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Helps excrete glucose and sodium

With SGLT2 inhibited, excess glucose leaves the body through urine. Reduced sodium reabsorption lowers blood volume and intraglomerular pressure without raising heart rate.

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
Get Started

The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is Jardiance®?

Jardiance® (empagliflozin) is an FDA-approved treatment for type 2 diabetes, heart failure, and chronic kidney disease. Off-label, it's sometimes prescribed by doctors within a longevity medicine framework.

How do you take Jardiance®?

Jardiance® is a daily oral tablet, taken once daily in the morning, with or without food. Always follow dosage instructions from your doctor.

What are the side effects of Jardiance®?

The most frequently reported side effects are urinary tract infections and genital yeast infections, which can occur in both men and women because Jardiance® increases glucose in the urine. Increased urination, mild dehydration, and lower blood pressure are also common. These are typically mild and tend to resolve as your body adjusts, with good hydration, hygiene, and standard treatment. Tell your doctor if side effects persist or feel disruptive.

Who shouldn't take Jardiance®?

Jardiance® is not recommended for people with type 1 diabetes (due to an increased risk of diabetic ketoacidosis), severe kidney impairment (eGFR below 30 mL/min/1.73 m²), or during the second and third trimesters of pregnancy. 

Extra caution is warranted for people on insulin or sulfonylureas, on diuretics or blood-pressure medications, with a history of recurrent genital or urinary infections, or with prior lower-limb amputations or foot ulcers. Your doctor will review your full medication list and health history before prescribing.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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