Immortals Medicine topical treatment tube branded Immortals Medicine on a blue background, personalized prescription topical in the Bryan Johnson Blueprint longevity protocol

“Topical estradiol supports healthy vaginal tissue and reduces UTI recurrence, supporting longevity long past menopause.”
Dr. Carl, Immortals Medicine physician, portrait in white lab coat with arms crossed

– Carl Seger, MD, Chief Medical Officer
  • Support women’s health
  • Support longevity

Estradiol

Generic for Estrace®

From $26/mo*

Can support vaginal tissue as estrogen declines with age.

 
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Not sure? Take the quiz

*Billed quarterly with a three-month commitment paid up front.
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HSA/FSA
reimbursable

Founded by Bryan
Johnson
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No insurance
required

Fast, discreet
shipping
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Licensed US
pharmacies

Unlimited follow-up with licensed physicians
Shield with medical cross icon representing HSA and FSA eligibility at Blueprint Immortals

HSA/FSA
reimbursable
Dollar sign icon representing transparent pricing at Blueprint Immortals

No insurance
required
Laboratory flask with checkmark icon representing tested formulas at Blueprint Immortals

Licensed US
pharmacies

Founded by Bryan Johnson

Fast, discreet shipping

Unlimited follow-up with licensed physicians

$0

Membership fees

“Topical estradiol supports healthy vaginal tissue and reduces UTI recurrence, supporting longevity long past menopause.”
Dr. Carl, Immortals Medicine physician, portrait in white lab coat with arms crossed

– Carl Seger, MD, Chief Medical Officer
WHY ESTRADIOL

Estrogen production declines over time. Estradiol can help restore it.

With estradiol cream Without estradiol cream
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

HOW ESTRADIOL WORKS

Replenish estrogen.

Restore vitality.

Estradiol works locally on vaginal tissue. This can support tissue health, sexual function, and urinary health.
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Estrogen delivered locally

Estradiol cream is applied directly to vaginal tissue. It absorbs locally, with decreased risk of elevating estrogen levels elsewhere in the body.
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Healthy pH restored

As acidic pH returns, Lactobacillus can thrive again. This protective bacteria may help ease dryness, painful sex, recurrent UTIs, and incontinence.
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Tissue revitalized

Vaginal, urethral, and bladder tissue absorbs estradiol locally. This can help restore epithelial thickness, moisture, and acidic pH.

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

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The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
Get Started

The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is estradiol?

Estradiol cream (generic for Estrace®) is an FDA-approved topical estrogen prescribed for certain symptoms related to menopause, including vaginal dryness and painful sex. 

How do you use estradiol?

Estradiol cream is inserted into the vagina using the included applicator. Your doctor determines the dosage based on your needs and medical history.

What are the side effects of estradiol?

The most frequently reported side effects are local irritation, burning, itching, vaginal discharge, and occasional spotting. These are typically mild and tend to appear in the first weeks of use, resolving as the tissue adjusts. Tell your doctor if side effects persist or feel disruptive.

Who shouldn't use estradiol?

Estradiol cream should not be used by people with a history of hormone-sensitive cancers (such as breast or uterine cancer), as estrogen exposure can increase the risk of recurrence. It is also not recommended for people with unexplained vaginal bleeding, a history of blood clots, stroke, or active liver disease. Your doctor will review your full medical history before prescribing.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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