Medicine bottle labeled 'Immortals Medicine' with 'Tadalafil' on a blue background

"Tadalafil enhances my endothelial function, reduces my inflammation markers, and potentially protects me against age-related cardiovascular and metabolic decline."

Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
  • What Bryan takes
  • Support longevity
  • Have better sex

Daily Tadalafil

Generic for Cialis®

From $24/mo*

$40/mo

Can help relax blood vessels, supporting sexual function, vascular health, and healthy aging.
Medication Type
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*Billed quarterly with a three-month commitment paid up front.
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HSA/FSA
reimbursable

Founded by Bryan
Johnson
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No insurance
required

Fast, discreet
shipping
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Licensed US
pharmacies

Unlimited follow-up with licensed physicians
Shield with medical cross icon representing HSA and FSA eligibility at Blueprint Immortals

HSA/FSA
reimbursable
Dollar sign icon representing transparent pricing at Blueprint Immortals

No insurance
required
Laboratory flask with checkmark icon representing tested formulas at Blueprint Immortals

Licensed US
pharmacies

Founded by Bryan Johnson

Fast, discreet shipping

Unlimited follow-up with licensed physicians

$0

Membership fees

"Tadalafil enhances my endothelial function, reduces my inflammation markers, and potentially protects me against age-related cardiovascular and metabolic decline."

Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
WHY TADALAFIL

Blood vessels tighten as you age. Tadalafil helps keep them open.

With tadalafil Without tadalafil
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

HOW TADALAFIL WORKS

Opens blood vessels.

Supports circulation.

Tadalafil works on one enzyme in your vascular system. This single action supports vascular health, sexual function, and longevity.
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PDE5 inhibited

Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, the chemical signal that keeps blood vessels relaxed.
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Vascular function supported

This vasodilation effect has been shown to help support sexual function (the FDA-approved use). But the same effect works throughout your vascular system. Daily low-dose use may also support cardiovascular and endothelial health.
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cGMP preserved

cGMP can then stay active longer. This helps blood vessels stay relaxed which can help keep circulation running smoothly.

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
Get Started

The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is tadalafil?

Tadalafil (generic for Cialis®) is an FDA-approved PDE5 inhibitor prescribed for erectile dysfunction and benign prostatic hyperplasia. Some physicians also prescribe it off-label at low daily doses within longevity protocols.

How do you take tadalafil?

Tadalafil is a daily tablet, taken with or without food. It can be prescribed as-needed or daily. Your doctor determines the dosage based on your needs and medical history.

What are the side effects of tadalafil?

The most frequently reported side effects are headache, flushing, nasal congestion, and back pain. These are typically mild and tend to resolve as your body adjusts. Tell your doctor if side effects persist or feel disruptive.

Who shouldn't take tadalafil?

Tadalafil should not be taken with nitrate medications (used for chest pain or heart conditions), because the combination can cause dangerous drops in blood pressure. 

It is also not recommended for people with severe heart disease, recent heart attack or stroke, or severe liver or kidney problems. Your doctor will review your full medication list and health history before prescribing.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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