Immortals Medicine topical treatment tube branded Immortals Medicine on a blue background, personalized prescription topical in the Bryan Johnson Blueprint longevity protocol

“Tretinoin is the gold-standard topical anti-aging agent, with robust clinical trial evidence demonstrating improvements in fine wrinkling, hyperpigmentation, and collagen synthesis in photodamaged skin. It is a core part of my skincare protocol.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
  • What Bryan takes
  • Renew skin

Tretinoin

From $25/mo*

$45/mo

Stimulates collagen production, improves skin texture, and reverses photoaging.
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Not sure? Take the quiz

*Billed quarterly with a three-month commitment paid up front.
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HSA/FSA
reimbursable

Founded by Bryan
Johnson
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No insurance
required

Fast, discreet
shipping
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Licensed US
pharmacies

Unlimited follow-up with licensed physicians
Shield with medical cross icon representing HSA and FSA eligibility at Blueprint Immortals

HSA/FSA
reimbursable
Dollar sign icon representing transparent pricing at Blueprint Immortals

No insurance
required
Laboratory flask with checkmark icon representing tested formulas at Blueprint Immortals

Licensed US
pharmacies

Founded by Bryan Johnson

Fast, discreet shipping

Unlimited follow-up with licensed physicians

$0

Membership fees

“Tretinoin is the gold-standard topical anti-aging agent, with robust clinical trial evidence demonstrating improvements in fine wrinkling, hyperpigmentation, and collagen synthesis in photodamaged skin. It is a core part of my skincare protocol.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
WHY TRETINOIN

Increases skin cell turnover. Improves photoaged skin.

With tretinoin Without tretinoin
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

HOW TRETINOIN WORKS

Renews skin cells.

Rebuilds collagen.

Tretinoin is the active form of vitamin A. When applied to the skin, it enters cells and activates receptors that influence how skin cells grow, divide, and mature. Over time, this can lead to faster cell turnover, increased collagen production, and smoother, more even-looking skin.
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Activates retinoic acid receptors

When applied to the skin, tretinoin enters skin cells and activates genes involved in how skin cells grow, divide, and mature.
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Boosts skin cell turnover

Tretinoin speeds up the rate at which old skin cells shed, restoring a pace of turnover that naturally slows with age and sun exposure. Over weeks to months, skin texture can smooth out, tone typically becomes more even, and fine lines may become less visible. Improvement is gradual and builds with consistent use.
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Increases collagen production

That same signal prompts cells in the deeper layer of skin (fibroblasts) to produce more collagen — the protein responsible for firmness and resilience.

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

Get Started

The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
Get Started

The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is tretinoin?

Tretinoin is an FDA-approved topical retinoid for acne, visible signs of sun damage, fine lines, uneven tone, and rough texture. Off-label, doctors often include it in broader skin health protocols for its effects on collagen and long-term skin quality.

How do you take tretinoin?

Doctors typically recommend applying tretinoin to clean, dry skin. 

Tretinoin significantly increases sensitivity to the sun. Wash your face in the morning and apply a broad-spectrum sunscreen every day, even on cloudy days. Skipping this step can lead to significant sunburn and post-inflammatory discoloration that is difficult to treat.

What are the side effects of tretinoin?

Most people experience some dryness, flaking, or redness in the first few weeks. This is normal and usually settles as skin adjusts. Starting slow helps. Tell your doctor if irritation feels persistent or severe.

Who shouldn't take tretinoin?

Tretinoin isn't recommended during pregnancy or on broken or sunburned skin. Your doctor will go through your skin history and any other products or medications you're using before prescribing.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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