Immortals Medicine amber prescription bottle labeled Metformin on a blue background, FDA-approved type 2 diabetes medication for glucose control in the Bryan Johnson Blueprint longevity protocol

“I've taken metformin for years as part of my longevity stack. It activates AMPK — a cellular energy sensor that mimics some effects of caloric restriction — and has anti-inflammatory properties supported by decades of observational data. I cycle it in 6-week intervals to avoid any potential interference with exercise-driven adaptations."
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– Bryan Johnson
  • Support longevity
  • Support weight loss

Metformin

From $20/mo*

$35/mo

Activates AMPK, the body's cellular energy switch, supporting steadier blood sugar, metabolic health, and longevity.
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HSA/FSA Eligible
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No insurance required
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Licensed US pharmacies

Founded by Bryan Johnson

Fast, free, and discreet shipping

Unlimited follow-up with licensed physicians

$0

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*Billed quarterly with a three-month commitment paid up front.

“I've taken metformin for years as part of my longevity stack. It activates AMPK — a cellular energy sensor that mimics some effects of caloric restriction — and has anti-inflammatory properties supported by decades of observational data. I cycle it in 6-week intervals to avoid any potential interference with exercise-driven adaptations."
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
WHY METFORMIN

Metformin may target pathways linked to biological aging.

GPD1 pathway biology Typical biology
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

HOW METFORMIN WORKS

Activates AMPK.

Mimics fasting.

Metformin works on an energy-sensing pathway in your cells. This can support: blood sugar control, cellular aging, and metabolic health.
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Activates AMPK

Metformin activates AMPK, a cellular switch that turns on when energy runs low. When it's on, the body shifts into repair mode, using energy more efficiently and reducing excess glucose production.
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Reduces glucose

Metformin can reduce the liver's tendency to release sugar into the bloodstream between meals. The result is steadier blood sugar throughout the day and less strain on insulin production.
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Suppresses mTOR

AMPK activation signals the body to dial back mTOR, the pathway that drives cell growth. Keeping mTOR in check is associated with slower cellular aging, and mirrors what the body does during caloric restriction.

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

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The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
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The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is metformin?

Metformin is an FDA-approved medication for type 2 diabetes. Off-label, doctors sometimes prescribe it within a longevity framework given growing evidence of its effects on the cellular pathways associated with biological aging.

How do you take metformin?

Metformin is an oral tablet taken with meals. Always follow the dosage instructions from your doctor.

What are the side effects of metformin?

Common side effects include nausea, loose stools, and stomach discomfort, especially in the first few weeks. These should settle as your body adjusts. Contact your doctor if side effects are persistent or bothersome.

Who shouldn't take metformin?

Metformin is not recommended for people with severe kidney impairment, a known hypersensitivity to metformin, or acute metabolic acidosis including diabetic ketoacidosis. Extra caution applies to patients over 65 and those scheduled for imaging procedures using iodinated contrast. Your doctor will review your kidney function and full health history before prescribing.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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