Immortals Medicine topical treatment tube branded Immortals Medicine on a blue background, personalized prescription topical in the Bryan Johnson Blueprint longevity protocol

“Tretinoin is the gold-standard topical anti-aging agent, with robust clinical trial evidence demonstrating improvements in fine wrinkling, hyperpigmentation, and collagen synthesis in photodamaged skin. It is a core part of my skincare protocol.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
  • Renew skin
  • Explore peptides

Peptide Skin Complex (4-in-1)

Tretinoin with Niacinamide/Caffeine/Copper Tripeptide

From $133/mo*

$185/mo

A 4-in-1 topical cream including tretinoin, caffeine, copper tripeptide, and niacinamide. Helps reduce fine lines, fade dark spots, rebuild collagen, and brighten skin tone.
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Not sure? Take the quiz

*Billed quarterly with a three-month commitment paid up front.
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HSA/FSA
reimbursable

Founded by Bryan
Johnson
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No insurance
required

Fast, discreet
shipping
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Licensed US
pharmacies

Unlimited follow-up with licensed physicians
Shield with medical cross icon representing HSA and FSA eligibility at Blueprint Immortals

HSA/FSA
reimbursable
Dollar sign icon representing transparent pricing at Blueprint Immortals

No insurance
required
Laboratory flask with checkmark icon representing tested formulas at Blueprint Immortals

Licensed US
pharmacies

Founded by Bryan Johnson

Fast, discreet shipping

Unlimited follow-up with licensed physicians

$0

Membership fees

“Tretinoin is the gold-standard topical anti-aging agent, with robust clinical trial evidence demonstrating improvements in fine wrinkling, hyperpigmentation, and collagen synthesis in photodamaged skin. It is a core part of my skincare protocol.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
WHY TRETINOIN

Increases skin cell turnover. Improves photoaged skin.

With tretinoin Without tretinoin
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of the referenced medication. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes or expected results.

HOW PEPTIDE SKIN COMPLEX WORKS

Rebuilds skin at every layer.

Tretinoin stimulates collagen production and reduces pigmentation, caffeine provides antioxidant defense. Copper tripeptide can improve skin elasticity. Niacinamide may even skin tone at the surface.
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Accelerates skin cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.
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Improves complexion

Can reduce melanin production, and redness, fading dark spots and brightening out skin tone.
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Stimulates collagen production

Fibroblasts are activated, producing new collagen, and helping reverse structural damage from UV exposure.

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

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The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
Get Started

The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is Peptide Skin Complex (4-in-1)?

Peptide Skin Complex contains caffeine, Copper tripeptide, tretinoin, and niacinamide in one topical cream. It can target hyperpigmentation, fine lines, and uneven texture.

How do you use Peptide Skin Complex?

Cleanse face and neck thoroughly and pat dry. Apply a thin layer of Peptide Skin Complex to affected areas or entire face once daily in the evening as prescribed.

Tretinoin increases sensitivity to the sun. Always follow with a broad-spectrum sunscreen during the day.

What are the side effects of Peptide Skin Complex?

Common side effects include mild redness or irritation, dryness, peeling, burning, and sensitivity.

When to expect results?

Meaningful improvements in collagen and texture typically take 3–6 months of consistent use. Stopping too early is the most common reason people don't see results.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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