Immortals Medicine topical treatment tube branded Immortals Medicine on a blue background, personalized prescription topical in the Bryan Johnson Blueprint longevity protocol

“Tretinoin is the gold-standard topical anti-aging agent, with robust clinical trial evidence demonstrating improvements in fine wrinkling, hyperpigmentation, and collagen synthesis in photodamaged skin. It is a core part of my skincare protocol.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
  • Support women’s health
  • Renew skin

Women’s Skin Complex (4-in-1)

Estriol/Finasteride/Tretinoin with Niacinamide

From $65/mo*

$95/mo

A 4-in-1 topical cream combining estriol, finasteride, tretinoin, and niacinamide to target visible signs of aging.

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HSA/FSA Eligible
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No insurance required
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Licensed US pharmacies

Founded by Bryan Johnson

Fast, free, and discreet shipping

Unlimited follow-up with licensed physicians

$0

Membership fees
Not sure? Take the quiz

*Billed quarterly with a three-month commitment paid up front.

“Tretinoin is the gold-standard topical anti-aging agent, with robust clinical trial evidence demonstrating improvements in fine wrinkling, hyperpigmentation, and collagen synthesis in photodamaged skin. It is a core part of my skincare protocol.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
WHY TRETINOIN

Increases skin cell turnover. Improves photoaged skin.

With tretinoin Without tretinoin
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class or active ingredient. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes. References to medication classes, mechanisms, or published studies are intended to illustrate general pharmacologic concepts and do not establish that any specific medication, formulation, or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.

HOW WOMEN’S SKIN COMPLEX WORKS

Rebuilds collagen.

Improves skin texture.

Tretinoin switches on genes responsible for producing collagen and regulating pigmentation. Niacinamide evens tone at the surface. Estriol hydrates the skin and increases elasticity. Finasteride blocks DHT, minimizing unwanted facial hair.
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Accelerates cell turnover

Dead skin cells shed faster. New cells reach the surface more quickly, improving texture and tone.
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Strengthens and restores skin

Estriol supports hydration and elasticity, while niacinamide strengthens the skin barrier, reduces redness, and brightens tone.
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Stimulates collagen production

Fibroblasts are activated to produce new collagen, partially reversing structural damage from UV exposure.

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

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The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
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The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is Women’s Skin Complex?

Women’s Skin Complex is a topical cream containing estriol, finasteride, tretinoin, and niacinamide. It targets fine lines, uneven skin texture, and unwanted hair growth.

How do you use Women’s Skin Complex?

Cleanse skin thoroughly and pat dry. Apply a pea-sized amount of Women’s Skin Complex (4-in-1) to face and neck, focusing on areas of concern. Use once daily in the evening. 

Tretinoin increases sensitivity to the sun. Always follow with a broad-spectrum sunscreen during the day.

What are the side effects of Women’s Skin Complex?

Common side effects include mild redness or irritation, dryness, peeling, burning, and sun sensitivity. These effects are typically temporary and should fade as your skin grows accustomed to treatment.

Who shouldn’t use Women’s Skin Complex?

May not be suitable for people who are pregnant, breastfeeding, or those with hormone-sensitive conditions. Your doctor will evaluate whether Women’s Skin Complex (4-in-1) is appropriate for you.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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