Immortals Medicine Semaglutide microdose injectable amber vial with blue label on a blue background, low-dose GLP-1 weight management therapy

“There has been growing scientific data suggesting that GLP-1 agonists are beneficial for longevity via several mechanisms that are independent from weight loss.”
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– Bryan Johnson
  • Support longevity

Semaglutide Microdose (Injections)

Semaglutide/Glycine/B12

From $167/mo*

$245/mo

Microdosing semaglutide activates the GLP-1 pathway at lower doses, reducing side effects and may support longevity protocols.
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HSA/FSA Eligible
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No insurance required
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Licensed US pharmacies

Founded by Bryan Johnson

Fast, free, and discreet shipping

Unlimited follow-up with licensed physicians

$0

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*Billed quarterly with a three-month commitment paid up front.

“There has been growing scientific data suggesting that GLP-1 agonists are beneficial for longevity via several mechanisms that are independent from weight loss.”
Immortals homepage biohacking lifestyle image featuring Bryan Johnson and his Blueprint longevity protocol

– Bryan Johnson
WHY GLP-1s

Natural hormone breaks down in minutes. GLP-1s last days.

GLP-1s Natural GLP-1
Charts and graphics are illustrative representations intended to communicate published research findings and the known pharmacologic properties of a medication class or active ingredient. Visualizations may simplify, normalize, or model study data for educational purposes and should not be interpreted as guarantees of individual clinical outcomes. References to medication classes, mechanisms, or published studies are intended to illustrate general pharmacologic concepts and do not establish that any specific medication, formulation, or treatment program will produce identical results. Compounded medications are not evaluated by the FDA for safety, quality or efficacy.

HOW GLP-1 RA WORKS

Semaglutide activates GLP-1 receptors throughout the body.

Semaglutide is a GLP-1 receptor agonist (GLP-1 RA) that mimics the GLP-1 hormone produced in the gut. Receptors are located in the brain, gut, heart, and pancreas, where activation supports appetite regulation, blood sugar balance, and metabolic function.
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Activates GLP-1 receptors

GLP-1 is a hormone your gut produces naturally, lasting only 1-2 minutes in the body. GLP-1 receptor agonists are engineered to activate the same receptors for days instead of minutes, providing sustained appetite regulation and metabolic support.
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Preserves benefits

Research suggests that low dose semaglutide can activate longevity-relevant pathways including moderate weight loss, glycemic control, and liver health.
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Reduces side effects

Side effects from semaglutide are dose-dependent. In clinical trials, dropping from 2.4 mg to 1.0 mg reduced the rate of digestive side effects by 6% (absolute reduction).

HOW IMMORTALS MEDICINE WORKS

From intake to your door in three to seven days

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The same prescription framework as Bryan Johnson’s medical team.

Medical intake

Step 1

Medical intake

Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.

A few minutes
Doctor review

Step 2

Doctor review

A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*

Within 72 hours
Fast shipping

Step 3

Fast shipping

Approved medications ship directly to your door in discreet packaging.

2-5 business days
Unlimited messaging

Step 4

Unlimited messaging

Your doctor is available via chat any time for additional support. Video consults available.

Up to 12 months
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The same prescription framework as Bryan Johnson’s medical team.

*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.

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Why Immortals Medicine

Precision medicine protocols to support longevity

  • Proactive care

    Doctor-led treatment plans designed around your goals. No wait lists. No insurance required.

  • Transparent pricing

    No membership fees, no hidden costs. You pay only after a doctor prescribes treatment.

  • Board-certified doctors

    Access to specialist physicians, licensed in your state. Unlimited messaging for up to 12 months.

  • Curated by longevity experts

    Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.

COMMON QUESTIONS

Questions, answered

What is Semaglutide Microdose?

Low-dose semaglutide is an emerging therapeutic for patients who experience side effects at standard doses. Early research suggests it may preserve the same longevity-relevant mechanisms as higher doses, including glycemic control, liver health, inflammation, and oxidative stress.

How do you take Semaglutide Microdose?

Semaglutide Microdose is available via Immortals Medicine in a weekly injectable form. Your provider will determine which medication and dose is appropriate for you. Always follow instructions from your doctor.

What are the side effects of Semaglutide Microdose?

Higher doses of semaglutide are associated with more side effects. In the STEP 2 trial, 63.5% of patients experienced GI side effects at 2.4 mg compared to 57.5% at 1.0 mg — a 6 percentage point reduction.

A titration study starting at 0.0675 mg and increasing gradually showed even greater impact: side effect-related dropouts fell from 19% to 2%, and nausea days dropped by more than half.

At full dose, the most common side effects are nausea, diarrhea, vomiting, constipation, abdominal pain, headache, and fatigue. Lower doses and slower titration can reduce the frequency of these side effects.

Who shouldn’t take Semaglutide Microdose?

Not recommended for people with a personal or family history of medullary thyroid cancer or MEN2. Your doctor will evaluate whether Semaglutide Microdose is appropriate for you.

Disclaimer: This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment. Always consult a licensed healthcare professional before beginning any wellness program

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