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♀ Female
Arousal response
PDE5 inhibitors can increase blood flow to clitoral and vaginal tissues, supporting physiological arousal response.
Int. Journal of Gynaecology & Obstetrics2016Proactive careBoard-certified doctorsProtocols by longevity expertsFounded by Bryan JohnsonFast, discreet shippingNo membership feesHSA/FSA reimbursableProactive careBoard-certified doctorsProtocols by longevity expertsFounded by Bryan JohnsonFast, discreet shippingNo membership feesHSA/FSA reimbursable
Should erection meds only
be for men?
Tadalafil (generic for Cialis®) can help relax blood vessels, supporting sexual function, vascular health, and healthy aging.
Daily Tadalafil
From
$24
/mo
Regular price$40/mo
Save 40%
*Billed quarterly with a three-month commitment paid up front.
Get Started
No insurance required
Cancel anytime
Not sure? Take the intake
Board-certified doctors
HSA/FSA reimbursable
Licensed U.S. pharmacies
Fast, discreet shipping
How tadalafil works
Arterial elasticity degrades with age.
Tadalafil can help preserve it.
Tadalafil works on an enzyme in your vascular system to keep blood vessels open. The same action that supports erection health may also support vascular health, regardless of gender.
-
1
Inhibits PDE5
Tadalafil inhibits PDE5, the enzyme that breaks down cGMP, the chemical signal that keeps blood vessels relaxed.
-
2
Preserves cGMP
cGMP stays active longer. Blood vessels stay relaxed, which helps keep circulation running smoothly.
-
3
Vascular support
This vasodilation effect has been shown to help support sexual function and may also support cardiovascular and endothelial health.
The system is broken.
How decades of research left women behind.
Women barred from drug trials.
Until 1993, women were barred from early drug trials in the U.S. By the time that changed, the entire pipeline was already built around male bodies. Research on ED medication was developed within a male-focused system.
Male demand funded male research.
ED medications became a blockbuster. Sex sells. That revenue paid for more trials. More trials unlocked more approvals. More approvals paid for more trials.
Then the window closed.
Once the patents expired, no company would spend $50–100M proving a medicine works in women when any competitor could sell the same generic. Without financial incentives, on-label approval for women may never come.
The research gap
50:1
Men in trials
Women in trials
50,620 men have received PDE5 inhibitors in clinical trials compared to fewer than 1,000 women. But the evidence points to benefits regardless of gender.
♀ Female
♀ Female
SSRI-related arousal
PDE5 inhibitors show potential benefits for arousal difficulties in women experiencing antidepressant-associated arousal dysfunction.
New England Journal of Medicine2024
♂ Male
Neuroprotection
A meta-analysis pooling six studies and 8.3 million participants found PDE5 inhibitor use was associated with reduced Alzheimer's risk.
Neurological Sciences2024
♂ Male
Cardiovascular health
Research linked tadalafil users to fewer major cardiovascular events, including heart attacks, strokes, and heart failure.
Clinical Cardiology2024
♂ Male
Lower all-cause mortality
A study of over 29,000 men found tadalafil users had lower all-cause mortality than non-users.
Clinical Cardiology2024
♂ Male
Anti-inflammatory pathways
Research showed tadalafil normalized elevated pro-inflammatory markers in patients with chronic inflammation, suggesting systemic anti-inflammatory effects.
Scientific Reports2019Immortals
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Every protocol is built by medical experts, based on longevity research from Bryan Johnson's science team.
Common questions
Questions, answered
What is tadalafil?
Tadalafil (generic for Cialis®) is an FDA-approved PDE5 inhibitor prescribed for erectile dysfunction and benign
prostatic hyperplasia. Some physicians also prescribe it off-label at low daily doses within longevity protocols.
How do you take tadalafil?
Tadalafil is a daily tablet, taken with or without food. It can be prescribed as-needed or daily. Your doctor
determines the dosage based on your needs and medical history.
What are the side effects of tadalafil?
The most frequently reported side effects are headache, flushing, nasal congestion, and back pain. These are
typically mild and tend to resolve as your body adjusts. Tell your doctor if side effects persist or feel disruptive.
Who shouldn't take tadalafil?
Tadalafil should not be taken with nitrate medications (used for chest pain or heart conditions), because the
combination can cause dangerous drops in blood pressure. It is also not recommended for people with severe
heart disease, recent heart attack or stroke, or severe liver or kidney problems. Your doctor will review your full
medication list and health history before prescribing.
The information provided on this page is for educational purposes only and is not intended to provide diagnosis, treatment, or medical advice. Always discuss treatment options with your provider.