The peptide your skin loses with age. Prescribed back.
A breathable nightly topical that pairs copper peptides with clinical-grade tretinoin to support skin regeneration at the cellular level.
Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use.
BestsellerClinically-backed ingredients support collagen production and skin elasticity
Supports plump, toned skin over time
Helps reduce hyperpigmentation and photoaging
Softens the look of fine lines
*If your skin is highly sensitive, tell your provider. They may recommend easing in with every-other-night application before advancing to nightly use.
Core Actives
Four clinically-backed actives, dosed to work together in one nightly topical. Select any to see the research.
Actives at Work
Begins rebuilding collagen from week one. 70% of women showed increased collagen production after just one month.
Pickart & Margolina, BioMed Res Int 2015Kicks off skin renewal by week 4. A brief adjustment period is normal, and at this strength irritation stays minimal.
Andreano et al., Cleve Clin J Med 1993Supports antioxidant protection on application. Caffeine rapidly penetrates the skin barrier and helps defend against UV-induced oxidative stress from day one.
Li et al., Theranostics 2018Fades early discoloration and strengthens the barrier. Visible skin lightening and reduced hyperpigmentation are measurable by week 4.
Hakozaki et al., Br J Dermatol 2002Drives visible wrinkle improvement. In an 8-week comparison, tretinoin performed as the prescription wrinkle benchmark.
Fu et al., Br J Dermatol 2010Keeps antioxidant protection working daily. Continued use maintains defense against UV-induced oxidative stress.
Li et al., Theranostics 2018Hits its clinical stride by week 8. 5% niacinamide produced measurable reductions in fine lines, wrinkles, spots, and redness by week 8.
Bissett et al., Dermatol Surg 2005Reaches peak results at 12 weeks. In 71 women, GHK-Cu cream reduced wrinkle depth and increased skin density and thickness after 12 weeks.
Pickart & Margolina, BioMed Res Int 2015Results keep deepening. Improvement in fine wrinkles and pigmentation continues to build, with clear gains by 24 weeks.
Andreano et al., Cleve Clin J Med 1993Completes its 12-week arc. By week 12, elasticity measurably improved alongside smoother tone and texture.
Bissett et al., Dermatol Surg 2005Consistent use keeps the skin's repair cycle active. Copper peptide builds new collagen and slows collagen breakdown, so the skin stays in build mode.
Pickart & Margolina, Int J Mol Sci 2018After 10–12 months of daily use, tretinoin raises collagen I formation by 80%.
The clinical data referenced describes the known properties of each active ingredient and is provided for educational purposes only. It is not a claim of therapeutic equivalence to any FDA-approved product, nor a guarantee of identical outcomes from the compounded formulation.
From intake to your door in three to seven days
Answer a guided set of questions covering your medical history, current medications, goals, and treatment preferences.
A U.S.-licensed, board-certified physician reviews your intake and recommends a medication, if appropriate.*
Approved medications ship directly to your door in discreet packaging.
Your doctor is available via chat any time for additional support. Video consults available.
*Some states may require a synchronous audio and/or video consultation prior to a prescription being approved.
Questions, answered
What is Peptide Skin Complex (4-in-1)?
Peptide Skin Complex contains caffeine, GHK-Cu, tretinoin, and niacinamide in one topical cream. It can target hyperpigmentation, fine lines, and uneven texture.
How do you use Peptide Skin Complex?
Cleanse face and neck thoroughly and pat dry. Apply a thin layer of Peptide Skin Complex to affected areas or entire face once daily in the evening as prescribed. Tretinoin increases sensitivity to the sun. Always follow with a broad-spectrum sunscreen during the day.
What are the side effects of Peptide Skin Complex?
Common side effects include mild redness or irritation, dryness, peeling, burning, and sensitivity.
When to expect results?
Meaningful improvements in collagen and texture typically take 3–6 months of consistent use. Stopping too early is the most common reason people don't see results.
Disclaimer: Compounded medications are not FDA-approved, and the FDA does not evaluate them for safety, effectiveness, or quality prior to use. This page is intended for educational purposes only and is not intended to provide medical advice, diagnosis or treatment. Medication eligibility and prescriptions are determined solely by licensed medical providers based on clinical appropriateness. Not all individuals will qualify for medication-based treatment.
